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City Therapeutics

Private

City Therapeutics is a clinical-stage biotechnology company pioneering next-generation RNA interference (RNAi) medicines, founded by John Maraganore (former CEO of Alnylam Pharmaceuticals) and a team of RNAi pioneers. The company's lead platform is based on cleavage-inducing tiny guide RNAs (cityRNAs) designed to improve potency and durability over first-generation siRNA therapeutics, with three programs in the pipeline targeting cardiometabolic and rare diseases.

Company Info

Sector: Biotechnology / RNA Therapeutics
Headquarters: Cambridge, Massachusetts, USA
Founded: 2023
Funding Round: $99M financing (June 2026) to advance three RNAi programs into the clinic
Total Funding: $99M disclosed (June 2026 round)

Funding & Investor Relations

IPO Outlook / Plans

None publicly disclosed; private RNAi platform company focused on pipeline development.

Upcoming Milestones & Key Dates

H2 2026
Regulatory

First IND filing for CTX-001 cardiometabolic program

Late 2026 / 2027
Business Development

Pipeline expansion update and potential Series B or strategic partnership

Clinical Development Pipeline

CTX-001 (cityRNA lead program)

Target: Cleavage-inducing tiny guide RNA (cityRNA) targeting validated gene
Cardiometabolic disease (specific indication undisclosed)
Preclinical
Phase 1
Phase 2
Phase 3
Approved

CTX-002 (cityRNA program)

Target: cityRNA targeting tissue-specific gene
Rare disease (specific indication undisclosed)
Preclinical
Phase 1
Phase 2
Phase 3
Approved

CTX-003 (cityRNA program)

Target: cityRNA targeting CNS/ocular gene
CNS or ophthalmology indication (undisclosed)
Preclinical
Phase 1
Phase 2
Phase 3
Approved

Recent News

Leadership Team

John Maraganore

Founder and Chief Executive Officer (former CEO of Alnylam Pharmaceuticals)

To be confirmed

Chief Medical Officer

To be confirmed

Chief Scientific Officer

Careers & Job Openings

See all open roles

Multiple Departments
See careers page
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