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Ethyreal

Private

Ethyreal is a private clinical-stage biotechnology company developing antibody-based therapies for autoimmune endocrine disorders, with a focus on Graves' disease and the related thyroid eye disease (TED). Its lead candidate selectively targets the IGF-1 receptor pathway in orbital fibroblasts.

Company Info

Sector: Biotechnology / Autoimmune
Headquarters: South San Francisco, California, USA
Founded: 2022
Funding Round: Series A June 2026 ($101M)
Total Funding: $130M+ (cumulative)

Funding & Investor Relations

Notable Investors

  • Atlas Venture
  • Bain Capital Life Sciences
  • Forbion
  • OrbiMed
  • 5AM Ventures
  • Versant Ventures

IPO Outlook / Plans

None publicly disclosed; clinical-stage autoimmune biotech.

Upcoming Milestones & Key Dates

H2 2026
Clinical Trial

Phase 2 ETH-101 interim data in thyroid eye disease

Q1 2027
Clinical Trial

Phase 1 ETH-201 first-in-human readout in Graves' disease

Clinical Development Pipeline

ETH-101

Target: Anti-IGF-1R monoclonal antibody
Active moderate-to-severe thyroid eye disease (TED)
Preclinical
Phase 1
Phase 2
Phase 3
Approved

ETH-201

Target: Anti-TSHR antibody (modulating)
Newly diagnosed Graves' hyperthyroidism
Preclinical
Phase 1
Phase 2
Phase 3
Approved

ETH-301

Target: Anti-IGF-1R antibody combination
Graves' orbitopathy (preventive in newly diagnosed)
Preclinical
Phase 1
Phase 2
Phase 3
Approved

Recent News

Leadership Team

Dr. Jonathan Violin

Co-Founder and Chief Executive Officer

Dr. Shyh-Dar Shieh

Chief Medical Officer

Dr. Melissa Vroomen

Chief Scientific Officer

Careers & Job Openings

See all open roles

Multiple Departments
See careers page
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