Wave Life Sciences

NASDAQ: WVE ↗ $6.16 USD ~$700M MCAP

#RNA Therapeutics (Stereopure Oligonucleotides)#Obesity (INHBE / Activin E)#Huntington's Disease #Amyotrophic Lateral Sclerosis (ALS)#Frontotemporal Dementia (FTD)#Duchenne Muscular Dystrophy (DMD)#Alpha-1 Antitrypsin Deficiency (AATD)

Wave Life Sciences is a clinical-stage RNA medicines company using its proprietary PRISM platform to design stereopure oligonucleotides that target genetic diseases, metabolic disorders, and neurological conditions. Lead programs include WVE-006 for Alpha-1 Antitrypsin Deficiency (AATD), WVE-003 for Huntington's disease, WVE-007 for obesity, and WVE-N531 for Duchenne muscular dystrophy, with a strategic collaboration with GSK to accelerate development of RNA-based therapeutics.

Company Info

Sector: Biotechnology / RNA Therapeutics

Headquarters: Cambridge, Massachusetts, USA

Founded: 2012

Website: www.wavelifesciences.com/

Upcoming Milestones & Key Dates

Late 2026

Clinical Trial

WVE-006 (AATD) proof-of-mechanism data in patients

Mid-2026

Clinical Trial

WVE-003 (Huntington's) updated safety and biomarker data

Clinical Development Pipeline

WVE-006

Target: A-to-I RNA editing oligonucleotide (AIMer)

Alpha-1 Antitrypsin Deficiency (AATD) (partnered with GSK)

Preclinical

Phase 1

Phase 2

Phase 3

Approved

WVE-003

Target: Allele-selective antisense oligonucleotide

Huntington's disease (selectively targets mutant HTT allele)

Preclinical

Phase 1

Phase 2

Phase 3

Approved

WVE-N531

Target: Exon 53 skipping oligonucleotide

Duchenne muscular dystrophy (DMD)

Preclinical

Phase 1

Phase 2

Phase 3

Approved

WVE-007

Target: GalNAc-conjugated siRNA targeting INHBE in hepatocytes

Obesity (inhibits INHBE / Activin E for fat-mass reduction)

Preclinical

Phase 1

Phase 2

Phase 3

Approved

Paul Bolno, M.D., M.B.A.

President and Chief Executive Officer

Dr. Chandra Vargeese, Ph.D.

Chief Technology Officer

Dr. Erik Ingelsson, M.D., Ph.D., M.P.H.

Chief Medical Officer

Careers & Job Openings

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Multiple Departments

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